ABSTRACT
Objective@#To perform an epidemiological survey of the first case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Pinghu City of Jiaxing City, Zhejiang Province on March 13, 2022, so as to provide insights into the management of coronavirus disease (COVID-19) epidemics. @*Methods@#According to the requirements of the Protocol on Prevention and Control of COVID-19 (8th Edition), epidemiological investigations were performed among 39 cases with SARS-CoV-2 infections in Pinghu City from March 13 to 20, 2022. Cases' demographics, clinical symptoms, history of immunization and exposure were collected, and close contacts were identified. Pharyngeal swabs were sampled from infected cases for detection of SARS-CoV-2 nucleic acid and whole-genome sequencing, and the source of infection and transmission route were investigated. @*Results@#The index case for this COVID-19 epidemic was an imported case from Shanghai Municipality, who infected 6 persons via aerosol transmission when playing in the badminton venue of Pinghu National Fitness Center on March 9; subsequently, one of these infected cases infected another 18 persons when playing in the badminton venue of Jiadian Village Resident's Fitness Center in Zhapu Township on March 12. Sixteen confirmed cases were reported, and all cases were mild; another 23 asymptomatic cases were diagnosed, with no death reported. This epidemic occurred from March 11 to 20, with 3 generations of spread and a median incubation period of 3 days. The SARS-CoV-2 infected cases had a median age of 33.5 (interquartile range, 12.0) years and included 36 cases with a history of COVID-19 vaccination. There were 16 cases with fever, cough, runny nose and sore throat, and 13 cases with imaging features of pneumonia. The effective reproductive number (Rt) of the COVID-19 epidemic was 7.73 at early stage, and was less than 1 since March 21. Whole-genome sequencing identified Omicron BA.2 variant among 33 cases, which had high homology with the index cases. @*Conclusion@#This epidemic was a cluster of COVID-19 caused by imported Omicron BA.2 variant infection from Shanghai Municipality, and the COVID-19 transmission was mainly caused by indoor aerosols.
ABSTRACT
Objectives: To analyze lung cancer data of patients who are registered in Zhejiang province from 2010 to 2014 and describe the prevalence and mortality of lung cancer in residents of Zhejiang province, so as to provide a reference basis for the government and health administrative departments to formulate a strategy of cancer prevention and treatment. Methods: According to the report of 14 tumor registries of Zhejiang province from 2010 to 2014 in urban and rural areas, lung cancer incidence and mortality were calculated by gender, age, and urban or rural areas, respectively. The population structure from the 2000 national census and Segi's standard population was used to calculate the standardized rates and indicators such as the 0-74-year-old accumulation rates and 35-64-year-old truncation rates. Results: In 2010-2014, there were 37,227 new cases of malignant tumors of the trachea, bronchi, and lungs in Zhejiang cancer registration areas (which are referred to as lung cancer in this article; ICD10 was coded as c33-c34), with the crude incidence rates of 63.55 per 100,000, 35.73 per 100,000 for ASR China, and 35.54 per 100,000 for ASR world, accounting for 18.85% of all cancer cases. The cu-mulative rate of incidence in those aged 0-74 years was 4.44%. Of the new cases, 25,608 were men and 11,619 were women. The ASR China in male was as 2.26 times high as that in female. The ASR China in rural areas was as 1.12 times high as that in urban areas. There were 31,772 deaths in 2010-2014, with the crude mortality rates of 54.24 per 100,000, 29.39 per 100,000 for ASR China, and 29.05 per 100,000 for ASR world, accounting for 29.22% of all cancer deaths. Of the deaths, 22,796 were men and 8,976 were women. The ASR China in male was as 2.70 times high as that in female. The ASR China in rural areas was as 1.05 times high as that in urban areas. The age-specific incidence and mortality rates were relatively low before 40 years old, and increased dramatically after 40 years old, then reached peak at the age of 80 years old. Rates in male were generally higher than those in female. The age-specific incidence and mortality rates varied in urban and rural areas with similar curves. Conclusions: Lung cancer was the most common malignancy in Zhejiang province, and its incidence and mortality are both in the first place of all cancers . With the relatively high burden of disease, lung cancer should be regarded as one of the key malignant tumors while developing strategies for cancer prevention and treatment.